Nanomaterial Risk Levels (NRL)

Summary of Recommended Nanomaterial Risk Levels (NRL)
NRL Type of Nanomaterial Practices Engineering Controls Personal Protective Equipment (PPE)
1 Polymer matrix Standard Laboratory Practices including:
  • Lab Safety Plan should be updated with NRL defined
  • Labeling of storage containers of nanomaterials with both the chemical contents and the nanostructure form
Fume hoodor biological safety cabinet (Class II Type A1, A2 vented via a thimble connection, B1 or B2) Standard PPE (lab coat, gloves, safety glasses with side shields)
2 Liquid dispersion NRL-1 practice plus:
  • Use secondary containment for containers that store nanomaterials
  • Wipe contaminated areas with wet disposable wipes
  • Dispose of contaminated cleaning materials as segregated nanomaterial waste
Fume hoodor biological safety cabinet (Class II Type A1, A2 vented via a thimble connection, B1 or B2) orapproved vented enclosure (e.g., Flow Sciences vented balance safety enclosure [VBSE]) NRL-1 practice plus:
  • Nitrile gloves
  • Safety goggles
3 Dry powders or aerosols NRL-2 practice plus:
  • Vacuum with HEPA-equipped hand vacuum cleaner
  • Label work areas with "Caution Hazardous Nanoscale Materials in Use"
Fume hoodor biological safety cabinet (Class II Type A1, A2 vented via a thimble connection, B1 or B2) orapproved vented enclosure (e.g., Flow Sciences vented balance safety enclosure [VBSE]). HEPA filtered exhaust preferred for fume hoods containing particularly "dusty" operations. NRL-2 practice plus:
  • N95 respirators are required if work operation must be done outside of containment
4 Dry Powders or aerosols of parent materials with known toxicity or hazards NRL-3 practice plus:
  • Baseline medical evaluation or employees including physical exam, pulmonary function test (PFT) and routine blood work.
  • Access to the facility should be permitted only to persons who are knowledgeable about the hazards of the material and the specific control measures implemented to avoid exposures and/or environmental releases. These control measures should include work practices (SOPs), engineering controls, spill and emergency procedures, personal protective equipment, disposal procedures, and decontamination/clean up procedures. Department procedures should address the designation and posting of the laboratory, how access will be controlled, and any required entry and exit protocols.
Fume hoodor biological safety cabinet (Class II Type B1 or B2) or glove box or approved vented enclosure (e.g., Flow Sciences vented balance safety enclosure [VBSE]). HEPA filtered exhaust with Bag-In/Bag-Out capability preferred for hoods, BSCs, and gloveboxes. NRL-3 practice plus:
  • Need determined and respirator selected with reference to the engineering controls in use and potential for aerosol generation